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View on PubMed Lam et al

[DOI] [PMC free article] [PubMed] 78.Shahmiri M, Enciso M, Adda CG, Smith BJ, Perugini MA, Mechler A

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doi: 10.1016/j.heares.2012.03.007 11 BeckerB

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Ipamorelin and Gastric Motility Investigators have also examined Ipamorelins potential actions on gastric function , particularly gastric emptying rates .(6) In rodent models: Gastric emptying was quantified by measuring the percentage of a labeled solution remaining in the stomach 15 minutes after intragastric administration Surgical procedures were used to induce delayed gastric emptying in control animals In contrast to delayed controls, Ipamorelin-exposed animals showed: Faster gastric emptying Mitigation of slowed peristalsis Additional experiments evaluating gastric smooth muscle contractility indicated that Ipamorelin, especially when assessed alongside ghrelin, might enhance smooth muscle contractile responses elicited by acetylcholine and electrical field stimulation.(6) These observations suggest a potential prokinetic effect in experimental models